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Henry G. Manne received a B.A., cum laude, in Economics in 1950 at Vanderbilt University, his J.D. at the University of Chicago Law School in 1952, and his S.J.D. at Yale Law School in 1966. He holds honorary doctorates in law from Seattle University, Universidad Francisco Maraquin (Guatemala), and George Mason University. He is Dean Emeritus and University Professor Emeritus at the George Mason University School of Law, where he was Dean from 1986-1996 and University Professor from 1986 to 1999. He has also taught at St. Louis University, the University of Wisconsin, George Washington University, the University of Rochester, University of Miami, and Emory University. He is presently Distinguished Visiting Professor at Ave Maria Law School in Naples, FL.

He is a member of numerous professional organizations and boards, and an Honorary Life Member of the American Law and Economics Association, which honored him as one of the four founders of the field of Law and Economics. Professor Manne has published many books and articles, with emphasis on law and economics, the free market, and securities regulation. His development of the theory of a "market for corporate control" is credited with opening the entire field of corporate law to economic analysis, and his 1966 book, "Insider Trading and the Stock Market," began, and still heavily influences, the vast literature on that subject. He is a frequent contributor to the Wall Street Journal. The Liberty Fund, of Indianapolis, IN, recently published “The Collected Works of Henry G. Manne” in three volumes.

Among his notable educational innovations were the Law and Economics Center (LEC), the first academic center devoted to the development of the field of Law and Economics (presently part of the George Mason University School of Law); the Economics Institutes for Law Professors; the Law Institutes for Economists; the Economics Institutes for Federal Judges; the first specialized law degree program for Ph.D.'s in economics; and the first law school (George Mason) whose curriculum was built around the use of economics in law.